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Among people diagnosed with Alzheimer’s, researchers recognize familial forms of the disease and sporadic cases. This shifting appreciation of inherited risk, researchers say, is due to a better understanding of the role of a fourth gene that carries the blueprints to make a lipid-carrying protein called apolipoprotein E, known as APOE. One known as APOE2 is thought to be protective against the development of Alzheimer’s disease. They also compared people with two copies of APOE4 to people with other inherited forms of the disease — early-onset autosomal dominant Alzheimer’s disease (ADAD) and Down syndrome-associated Alzheimer’s disease (DSAD). Gene testing isn’t currently recommendedIt is also likely to change how people who carry the APOE4 gene are diagnosed and treated.
Persons: APOE4, , Dr, Juan Fortea, Sant, Fortea, Charles Bernick, Bernick, Alzheimer’s wasn’t, isn’t, they’re, ” Fortea, Sanjay Gupta, Reisa Sperling, , ” Sperling, ” Dr, Sterling Johnson, Johnson Organizations: CNN, Nature, National Alzheimer’s Coordinating, Neurology, Hospital de, Cleveland Clinic Lou, Brain Health, CNN Health, Alzheimer’s Research, Brigham, Women’s, Alzheimer’s, University of Wisconsin Locations: Alzheimer’s, Spain, United States, Santa, Barcelona, Wisconsin
It's easy to get sucked into watching "The Price is Right," the beloved TV game show where contestants win cash and prizes by guessing the price of merchandise. An investment analyst by trade, Bergner specialized in game theory at Yale University and has been a lifelong fan of TV show. Three contestants spin the wheel up to two times, aiming to be the closest to $1 without going over. Do one of these two things if you're the last bidder on Contestants' RowAs indicated above, if you're the last bidder on Contestants' Row, you're doing better already. Bid on the first showcase in the Showcase ShowdownAt the end of the show, two contestants face off in the Showcase Showdown.
Persons: Drew Carey, Justin L, Bergner, It's Organizations: Yale University
Products are seen at an Amazon fulfillment center where they are being sorted and shipped out as same-day orders during Cyber Monday at the Same-Day Delivery Facility Fulfillment Center in Tampa, Florida, on Nov. 27, 2023. The company has said it wants to make same- and next-day delivery the standard, and it plans to double the number of same-day delivery facilities in the U.S. within the next few years. Amazon has already stood up more than 55 same-day delivery sites in the U.S., primarily clustered around major metro areas. Same-day sites also condense the fulfillment process, typically spread across multiple Amazon facilities under one roof. Amazon has bolstered investment in fast shipping as traditional retail rivals Walmart and Target have stepped up their delivery game.
Persons: Andy Jassy Organizations: U.S, Amazon, Amazon's, RBC Capital, Walmart, Target Locations: Tampa , Florida, U.S
I had a home, and I also knew I wanted money. That's when I really started thinking about the life I wanted my children to live. Our kids save for their wantsBoth my kids earn money through doing chores. I want my kids to be motivated, not entitledThere are many things I'm able to give my kids that my parents couldn't give me. I'm thrilled to be able to offer my kids the kind of life I only saw on television.
Persons: , Stephanie Mearse, Joseph, Vincent, I'd, Tiffany, they'll, They'll Organizations: Service, Business
More than half, 55%, of all Americans say they see Trump’s presidency as a success, while 44% see it as a failure. Four years ago, he was able to assail Trump’s time in office from his position as a challenger. Biden won all three in 2020 after Trump won them in 2016 in his victory over Democratic nominee Hillary Clinton. In the poll, 92% of Republicans view Trump’s time in office a success, while just 73% of Democrats say Biden’s has been a success. And while 85% of Democrats polled say they back Biden, 91% of Republicans say they support Trump.
Persons: Joe Biden, Donald Trump, he’s, William Barr, Trump, CNN he’d, Ron DeSantis, Biden, Robert F, Kennedy Jr, , Israel, Mike Johnson, Benjamin Netanyahu, underscoring, Hillary Clinton, South Carolina Republican Sen, Lindsey Graham, CNN’s Dana, Nikki Haley, Biden’s, CNN’s Kristen Holmes, Kit Maher, CNN’s Kaitlan Collins, Trump . Barr, Trump’s, Chris Sununu, Haley, , Georgia —, ” Biden, He’s, Colin Jost, , ” Jost, Washington Hilton Organizations: CNN, GOP, Republican Party, Florida Gov, Trump’s, Democratic, Columbia University, National Guard, Israel, DeSantis, CBS, Biden, Trump, Trump ., South Carolina Republican, South Carolina Gov, New, New Hampshire Gov, , White, Republican, Washington Locations: New York, Gaza, Manhattan, Rafah, Michigan , Pennsylvania, Wisconsin, “ State, New Hampshire, Georgia, Ukraine, Russia, Israel, American
A recent tech grad received offers from Google, Meta, and Microsoft. Meta initially offered $210,700 in total compensation, but Google offered other appealing benefits. Right as I was about to accept my offer from Meta, Google let me know that they found a match for me. I would have chosen Google either wayIf Google didn't increase its total compensation offer, I would've had a really tough decision to make. Before college and working in tech, Google was a name that stood out to me.
Persons: , FANG, Meta, would've Organizations: Google, Microsoft, Meta, Service, Facebook, Netflix
In front of television cameras and a gaggle of journalists, former President Donald Trump wished his wife, Melania Trump, a very happy birthday Friday morning, moments before he entered the courtroom for his criminal hush-money trial. "I want to start by wishing my wife Melania a very happy birthday," he told reporters in the downtown Manhattan courthouse hallway. Trump is spending the day in Manhattan's criminal court, where he's on trial for charges alleging that he falsified business documents to disguise payments to porn star Stormy Daniels. AdvertisementTrump did not address why Melania Trump, or any of his other family members, have not attended the trial to support him. Trump said he listened to the arguments Thursday night, after his court day in Manhattan, and "thought it was really great."
Persons: , Donald Trump, Melania Trump, Trump, Stormy Daniels, Jason Miller, Boris Epshteyn, Waltine Nauta, Epshteyn, David Pecker, Pecker, Daniels, Karen McDougal Organizations: Service, Hallmark, Business, National Enquirer Locations: Manhattan, Florida, Arizona, Trump's Florida
From the courts to the campaign trail, former President Donald J. Trump is challenging a hallmark of American-style democracy: its suspicion of concentrated power. The Supreme Court will hear arguments on Thursday over Mr. Trump’s claim that criminal charges against him in the federal election subversion case must be thrown out because the Constitution makes him all but immune from being prosecuted for actions he took as president — no matter what the evidence may show. That vision of a presidency operating above the law dovetails with second-term plans that Mr. Trump and his allies are making to eliminate myriad internal checks and balances on the executive branch and to centralize greater power in his hands. That would include eliminating independent agencies and job protections for tens of thousands of senior civil servants.
Persons: Donald J, Trump, Trump’s,
Right-wing lawmakers are ramping up their threats to remove Speaker Mike Johnson from his role after Johnson’s supporters pushed him to make it harder to oust him from the speakership. The House is finished with floor action for the day, which means that the earliest that Greene could make a motion to oust Johnson would be on Friday. At one point, Johnson was surrounded on the House floor by a number of far-right lawmakers in a heated discussion. Democrats weigh how to proceedThe House Rules Committee is meeting Thursday morning to begin considering the foreign aid bills. One thing that is hanging over discussions is that many Democrats view Johnson as a more honest broker than McCarthy.
Persons: Mike Johnson, Johnson’s, Johnson, Kevin McCarthy, Marjorie Taylor Greene, Greene,  “, Matt Gaetz, Derrick Van Orden, Gaetz “ tubby, , Van Orden, ” Greene, “ Mike Johnson, CNN’s Manu Raju, , it’s, Anna Paulina Luna, , Luna, Dan Kildee, Pramila, ” Jayapal, Mike Quigley, ” Quigley, Jared Moskowitz, McCarthy, he’s, CNN’s Haley Talbot Organizations: CNN, Louisiana Republican, Georgia Rep, Republicans, Punchbowl News, GOP, Republican, Conservative, House Democratic Caucus, ” Democratic, Democrat, Democratic Locations: Louisiana, Ukraine, Israel, Taiwan, Washington,
New York CNN —Longtime broadcast journalist Robert MacNeil, who covered some of the biggest headlines of the 20th century and co-anchored PBS nightly news for two decades, died on Friday, PBS announced. MacNeil “was an incredibly erudite reporter, anchor and writer who raised the bar for serious journalism in America,” Sharon Percy Rockefeller, president of NewsHour Productions, said Friday in a news release. Arriving at PBS in the early 1970’s, MacNeil began a decades-long partnership with fellow journalist Jim Lehrer, according to PBS The two led PBS coverage of the Senate’s Watergate Hearings in 1973. In 1975, the pair co-founded the MacNeil/Lehrer Report, a show that would later become PBS NewsHour. MacNeil sat at the helm alongside Lehrer before leaving in 1995, according to PBS.
Persons: Robert MacNeil, MacNeil “, ” Sharon Percy Rockefeller, Jim Lehrer, MacNeil, John F, Kennedy, Lehrer, WETA, , Organizations: New, New York CNN, Longtime, PBS, NewsHour, NBC, WETA, Cuban Missile, MacNeil, Television, Writers ’ Conference Locations: New York, America, Montreal, Canada, Nova Scotia, London, Washington, DC, Dallas, WETA, United States
Constellation Brands reported better-than-expected quarterly earnings Thursday, driven by strength in its beer business that more than offset continued weakness in wines and spirits. Management's upbeat forecast for fiscal year 2025 should send the stock to new all-time highs. Constellation Brands Why we own it : We like Constellation Brands for its beer franchise, which includes popular Mexican brands Modelo, Corona and Pacifico. More importantly, the sales gains in the beer business are almost entirely driven by volume gains, not higher prices. Management cited Circana channel data as evidence that its beer business outperformed the total U.S. beer category and remained the top dollar sales share gainer.
Persons: Jim Cramer's, Bill Newlands, Beer, Crawford, Meiomi, Robert Mondavi, Jim Cramer, Jim, Justin Sullivan Organizations: Constellation Brands, Modelo, Anheuser, Busch Inbev, Molson Coors, Constellation, Modelo Especial, Corona, Pacifico, Management, High, Woodbridge, Lumina, Enterprise, CNBC Locations: Corona, Pacifico, STZ, Pacific, San Rafael , California
Amazon's TV series "Fallout" is based on the hugely popular games by Interplay and Bethesda SoftWorks. The show follows a young woman looking for her missing father in a postapocalyptic world. download the app Email address Sign up By clicking “Sign Up”, you accept our Terms of Service and Privacy Policy . Players have flocked to the "Fallout" games since 1997 to fight off raiders and slay monsters in a retrofuturistic wasteland ravaged by nuclear war. The makers of Prime Video's "Fallout" were wise, then, to develop a TV show with an original storyline that does indeed capture the games' sense of adventure and mystery.
Persons: , Prince of Persia, Hunter, Lucy MacLean, Ella Purnell, Lucy, Hank, Kyle MacLachlan, Hank MacLean, Jonathan Nolan, Lisa Joy, Lucy MacLean's, Lucy braving, Walton, Aaron Moten, who's, isn't, Matt Berry Organizations: Interplay, Bethesda SoftWorks, Service, Players, of Steel, Hollywood Locations: America, China
CNN —At Trump Media, it was the best of times, and it looks like it’s headed for the worst of times. Courtesy Jill FilipovicLast week, Trump Media was valued at nearly $11 billion, an astronomical sum for a money-losing company with a few million in revenue. Truth Social, Trump Media’s answer to Twitter/X, has fewer than 500,000 monthly active US users, compared to X’s 75 million. The Trump Media story, though, is a fascinating one because it is an amplified example of so much of the Trump playbook. “The first rule of cults is: you’re never in a cult,” cult expert Daniella Mestyanek Young told Jennifer Rubin of the Washington Post.
Persons: Jill Filipovic, Donald Trump’s, Trump, Michael Ohlrogge, he’s, MAGA, there’s, Rick Ross, Robert Jay Lifton, , , , you’re, Daniella Mestyanek Young, Jennifer Rubin Organizations: Twitter, CNN, CNN —, Trump Media, Trump, NYU, Washington Post, Republican, Republican Party, RNC Locations: New York, America
Seeking Balance, Tripping Up
  + stars: | 2024-03-27 | by ( Jim Rutenberg | ) www.nytimes.com   time to read: +1 min
The news that NBC had hired and then abruptly cut ties with the former Republican Party chair Ronna McDaniel this week may feel like a flashback for TV insiders and viewers. Once again, a major news network is on the defensive over an attempt to balance out its ranks of talking heads — a mainstay of the genre — with a pro-Trump surrogate whose qualifications for the role appeared to run counter to the basic tenets of journalism. McDaniel, after all, had been a prominent exponent of the false notion that the 2020 election was stolen from Donald Trump. As my colleague Alexandra Berzon and I reported yesterday, McDaniel was also at times involved in Trump’s attempts to stave off the certification of Joe Biden’s victory. While the crackup may seem as if it was inevitable in retrospect, it was also reflective of a hallmark of the Trump era: After two impeachments, a Capitol riot and numerous criminal indictments, the question of how to cover Trump is no closer to being solved.
Persons: Ronna McDaniel, McDaniel, Donald Trump, Alexandra Berzon, Joe Biden’s, Trump Organizations: NBC, Republican Party, Trump
This ritual, epitomized by high-profile engagements — such as Apple CEO Tim Cook's effusive overtures and statements of commitments to China — signals that American corporate titans think the strategy can still work. Tim Cook's narrative of China as "critical" to Apple , coupled with his admiration for the country's advanced manufacturing capabilities, embodies the ethos of this engagement playbook. Apple's Chief Executive Officer Tim Cook attends the China Development Forum in Beijing on March 24, 2024. It's not that the Apple CEO is doing anything wrong. Chinese Apple superfans jostled to enter the smartphone maker's newest store as it opened on March 21 night.
Persons: Tim Cook's, Tim Cook, Pedro Pardo, Jim McNerney, Xi Jinping's, Mark Zuckerberg, Deirdre O'Brien, Strstr, Xi, Xi Jinping, Li Qiang Organizations: Apple, American, titans, U.S, Apple's, China Development Forum, AFP, Getty, Boeing, Airbus, Volkswagen, Qualcomm, Google, Facebook, Huawei, Afp Locations: China, Beijing, Weibo, Shanghai
In June 2017 — as he was reeling from the end of his marriage of more than two decades and some of the most disastrous investments of his career — Bill Ackman, the billionaire hedge-fund financier, joined Twitter. He offered his early Twitter followers little of the drama that was part of his investing style and would later become a hallmark of his round-the-clock social media posts. Just a few months later, Mr. Ackman went on his first date with a Massachusetts Institute of Technology professor, Neri Oxman. He was instantly smitten, and asked her on that date if she was open to having children, he told the crowd last year at an awards dinner. They married the following year.
Persons: , Bill Ackman, Ackman, Neri Oxman, Oxman Organizations: Twitter, Massachusetts Institute of Technology
Shop at Amazon Shop at DreoTyphur Sous Vide Station If you’ve been wanting to venture into the benefits of cooking with Sous Vide, Typhur’s Sous Vide Station incorporates all functions of sous vide cooking into one unit, with a built-in tank, scheduling functions, and step-by-step cooking instructions on a large LCD display. Shop at Amazon Shop at TramontinaAdvertisementSustainability and alternative materialsEco-friendly materials are at the forefront of home and kitchen design. Shop at Amazon Shop at UmbraFull Circle Grate Expectations Stainless Steel Coarse Grater with Food Catcher Full Circle should be on your radar for eco-friendly cleaning tools and hydration solutions. From earth tones and pastels to vibrant collections, you can coordinate your kitchen in monochrome hues, prints, and textures. Shop at Amazon Shop at Walmart Shop at TargetLuma Nugget Countertop Ice Maker We've been searching for a more affordable nugget ice maker, and this small appliance from Luma might be the one.
Persons: It's, Dreo ChefMaker Combi Fryer, you’ve, Zyliss, Joe Derochowski, Dyson, Brabantia Organizations: Business, Shop, kraft, Cork, Walmart, Everest
Kevin Lamarque | ReutersThe Biden administration announced new automobile emissions standards Wednesday that officials called the most ambitious plan ever to cut planet-warming emissions from passenger vehicles. The rules come as sales of electric vehicles, which are needed to meet the standards, have begun to slow. The agency is finalizing the rule as sales of clean vehicles, including plug-in hybrid and fully electric vehicles, hit record highs last year. At the same time, the Democratic president needs cooperation from the auto industry and political support from auto workers, a key political voting bloc. White House press secretary Karine Jean-Pierre said Tuesday that White House officials "don't have any concerns" about the final EPA rule.
Persons: Joe Biden, Kevin Lamarque, Michael Regan, Regan, Biden, Karine Jean, Pierre, , we're, Manish Bapna, Amanda Leland, Dan Becker, Donald Trump, Becker, Trump, Biden's Organizations: Detroit Auto, Reuters, Biden, Environmental Protection Agency, EPA, Democratic, United Auto Workers union, White, Natural Resources Defense, Environmental Defense Fund, Center for Biological Diversity Locations: America, Detroit , Michigan, EVs, Detroit, China
Bentley Motors is pushing back its plans to exclusively offer all-electric vehicles by the end of this decade due to changing market conditions and a delay in its first EV. CEO Adrian Hallmark said the famed British luxury carmaker remains committed to carbon neutrality and exclusively offering EVs, but it now plans to do so a couple of years later. Bentley will continue offering plug-in hybrids alongside BEVs, or battery electric vehicles, past its previous target of 2030, Hallmark said. Bentley is among a growing number of automakers to change, delay or cancel ambitious EV plans as global adoption grows slower than many expected. The company now expects its first EV to be released in 2026, pushing back the release of the subsequent vehicles as well.
Persons: Adrian Hallmark, Bentley Organizations: Bentley, Hallmark
The royal family's PR strategy is in need of an update, experts say. The stoicism of the royal family's unofficial motto, "never complain, never explain," was a hallmark of Queen Elizabeth II's reign. Kate Middleton, Prince William, Prince Harry, and Meghan Markle at Windsor Castle. But it's just a motto," Prince Harry told Anderson Cooper during a January 2023 episode of "60 Minutes." Prince William, Prince of Wales and Catherine, Princess of Wales in February 28, 2023.
Persons: , Prince Harry, Meghan, Oprah, excoriating, Buckingham, Queen Elizabeth II's, Kate Middleton, Prince William, Meghan Markle, Chris Jackson, King Charles, Princess Diana, Kate, Sovereign Grant, Prince William —, Duke of, Anderson Cooper, Prince William , Prince of Wales, Catherine , Princess of Wales, Max Mumby, William's, William, Evan Nierman, Nierman, Elizabeth II, Benjamin Disraeli, Marie Claire, Kristen Meinzer, Stringer, Elizabeth, Meinzer, Queen Elizabeth, Charles, Diana's, Graham Smith, Danny Lawson, Smith Organizations: PR, Service, Getty, Sovereign, Daily, British, Hulton Locations: Windsor, Duchy, Lancaster, Duke of Cornwall, Cornwall, Kensington, Republic, Buckingham
The obsession with lavish weddings grew to a fever pitch in the years following the start of the Covid-19 pandemic. That’s bad news for wedding vendors who provide services like videography, photo booths and catering. Meanwhile, those vendors are facing a more worrisome existential threat: a looming drop in the overall number of weddings. But she said that so far in 2024, weddings are “cooling a bit.”A recent wedding where Gabrielle Stone served as the planner. In another life, some of those would-be couples who never met in 2020 could have gotten engaged this year.
Persons: , Shane McMurray, What’s, McMurray, Gabrielle Stone, ” Stone, Stone, Kay, Jared, Gina Drosos, , Z, ” McMurray, Toni Burrowes, Burrowes, didn't, Toni Burrowes “, Alyssa Young, We've, Alyssa Young “, it’s, ” Young, It’s Organizations: CNN, Signet Jewelers, Kay Jewelers, Signet, Alpha, University of Virginia, Brigham Young University, Bureau of Labor Statistics Locations: Boston, Zales, Central Florida, San Antonio, Texas
When I hit my 20s, my health started to change. I also learned that I had Lyme Disease — maybe from a tick bite at Yosemite — which can trigger autoimmune responses. And since 80% of autoimmune patients are women, it became clear to me that this was a women's health crisis that no one was paying attention to. In 2022, I launched WellTheory, a virtual care platform that offers evidence-based nutrition and lifestyle coaching to mitigate autoimmune symptoms. You don't need to look sick to be sick, so they often fly under the radar at workplaces.
Persons: Ellen Rudolph, Organizations: Yosemite Locations: Yosemite, New York
CNN —Concorde, the world’s fastest commercial aircraft, has been making a rare journey – floating down New York’s Hudson River. The British Airways Concorde, one of only 20 of the supersonic aircraft to ever fly, has been en route back to NYC’s Intrepid Museum after being sanded and recoated during several months of restoration. The last ever flight by a Concorde was made on November 26, 2003. That aircraft, known as Delta Foxtrot, is now housed in Aerospace Bristol, an aviation museum in the west of England. Tours of Intrepid’s Concorde will resume on April 4, the museum says.
Persons: CNN’s Barry Neild Organizations: CNN, Concorde, British Airways Concorde, NYC’s Intrepid Museum, Intrepid, British Airways, Singapore Airlines, Intrepid’s Concorde Locations: Hudson, Jersey City , New Jersey, New York, London, Concordes, Paris, Aerospace Bristol, England
Russian officials alleged Ukraine would build and detonate a dirty bomb against Russian forces and then blame the attack on Russia. Western intelligence agencies had received information that there were now communications among Russian officials explicitly discussing a nuclear strike. “It’s never a cut-and-​dry, black-​and-​white assessment,” the first senior administration official told me. Secretary of State Antony Blinken communicated US concerns “very directly” with Russian foreign minister Sergey Lavrov, according to senior administration officials. “We conducted a number of quiet conversations with core allies to go through our thinking,” the first senior administration official told me.
Persons: CNN —, Biden, Powers, , ” “, Chris McGrath, Vladimir Putin, Sergei Shoigu, “ It’s, NurPhoto, Antony Blinken, Sergey Lavrov, Mark Milley, General Valery Gerasimov, Joe Biden, Bill Burns, Sergey Naryshkin, Xi Jinping, Narendra Modi, Alexandr Demyanchuk, , Organizations: CNN, US, National Security Council, Kherson City, , UN, United Nations, Russian, Russian Armed Forces, CIA, Indian, Shanghai Cooperation Organization Locations: Russia, Ukraine, Hiroshima, Nagasaki, , Russian, Kherson, Ukrainian, France, Turkey, , Kyiv, India, China, Samarkand
Eli Lilly headquarters in Indianapolis, Indiana, US, on Wednesday, May 3, 2023. Eli Lilly said Friday that the Food and Drug Administration has pushed back its approval decision deadline for the drugmaker's experimental Alzheimer's treatment donanemab in a surprise move. The agency plans to call a last-minute meeting of its outside advisors to further review the treatment's safety and efficacy in a late-stage trial, Eli Lilly said. It's another setback for Eli Lilly, which is racing to compete with Biogen and Eisai. In 2021, the FDA approved an earlier, ill-fated Alzheimer's drug called Aduhelm from Biogen and Eisai, despite a negative recommendation from the agency's advisory panel.
Persons: Eli Lilly, Eli Lilly's, Leqembi, Anne White Organizations: and Drug Administration, FDA Locations: Indianapolis , Indiana, Biogen
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